Mechanisms and functions we dug into. Do you want to know why?
Today I’m super thrilled to share some insights as we dive into an exciting new phase at Quality Biotech Development & Cells (QBDC) focused on the remarkable impact of epigenetic analysis on cell productivity, bioprocessing and how we use ML/AI for our business cases. Today, we’re kicking things off by exploring the fascinating world of DNA methylation! ☝
Let’s get right to it:
DNA methylation is a key player in the arena of gene regulation. This process involves the addition of a methyl group to the DNA molecule—specifically at the cytosine base within a CpG dinucleotide context. It's a job performed by DNA methyltransferases (DNMTs), which ensure that these methyl groups are added precisely, ultimately influencing the patterns of gene expression in significant ways.
What’s particularly remarkable about DNA methylation is its role as a molecular switch that can turn genes on or off and it can also modulate its expression, all without changing the actual DNA sequence. This dynamic process is crucial for normal development, cellular differentiation, and maintaining genomic stability. However, when things go awry with methylation patterns, it can lead to serious processing issues, including OOS results for any given product.
In the bioprocessing field, the implications of understanding and manipulating DNA methylation are immense!
By adjusting these methylation states, we can supercharge the production of therapeutic proteins, streamline cell line development, and boost the overall efficiency of our bioprocesses. Soon we will be able to switch on and off specific genes as we need it to get our cells under perfect productivity conditions!
As we continue our exploration of DNA methylation, we’re unlocking 🔓 incredible potential for innovation and therapeutic breakthroughs. Let’s stay curious, driven, and committed as we push the boundaries of biotechnology together!